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There has been some inconsistency in the literature on the learning and memory promoting effects of REM sleep in particular, with some work describing paradoxical learning-promoting effects of REM sleep deprivation (Rasch et al., 2009

Tryptophan metabolism appears to be differentially altered in ME/CFS and FM, relative to healthy controls, potentially contributing to the symptoms of each condition

doi:10.4081/aiua.2015.3.190

Cardiac Stress: Altering energy metabolism can place undue stress on the heart